I suggest dual Desert Furies and Dual Annihilations. The Annihilation does more damage and drains 15 resistance which is also a decent amount.
Use Annihilations twice and you can drain 30 resistance.
Desert Fury= -24 resistance
Annihilation= -15 resistance
15+15+24+24 = 78
With a build like this, 78 resistance is drained. And with Annihilations doing high-damage you can crush your opponents in no time.